APT imaging of hepatocellular carcinoma signals an effective therapeutic response in advance of tumor shrinkage

APT imaging of hepatocellular carcinoma signals an effective therapeutic response in advance of tumor shrinkage

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Aim: The aim of this study was to assess the utility of weighted amide proton transfer (APTw) MRI in three different rodent models of tourettebrewing.com hepatocellular carcinoma (HCC).Methods: APTw MRI was evaluated in models of diethylnitrosamine (DEN) induced HCC, N1S1 syngeneic orthotopic xenograft and human HepG2 ectopic xenograft.Results: All models of HCC showed a higher APTw signal over the surrounding normal tissues.

In the DEN model, the APTw signal could differentiate HCC lesions from benign nodules.Intra-arterial administration of low-density lipoprotein docosahexaenoic acid (LDL-DHA) nanoparticles to N1S1 xenografts rapidly animationbengal.com lowered the tumor APTw signal within 72 h.Direct injections of LDL-DHA nanoparticles into HepG2 xenografts also showed similar therapeutic responses.

Conclusion: We have demonstrated the utility of APTw imaging in the diagnostic/therapeutic management of HCC.